De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation

Transdifferentiation is a complete and stable change in cell identity that serves as an alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of transdifferentiation have been limited to the replenishment of cells lost from preexisting structures, i.e., in the presence of...

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Veröffentlicht in:Nature
Hauptverfasser: Schaub, Johanna R., Huppert, Kari A., Kurial, Simone N. T., Hsu, Bernadette Y., Cast, Ashley E., Donnelly, Bryan, Karns, Rebekah A., Chen, Feng, Rezvani, Milad, Luu, Hubert Y., Mattis, Aras N., Rougemont, Anne-Laure, Rosenthal, Philip, Huppert, Stacey S., Willenbring, Holger
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597492/
https://ncbi.nlm.nih.gov/pubmed/29720662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0075-5
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