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Mechanism of Cardiac Troponin C Calcium Sensitivity Modulation by Small Molecules Illuminated by Umbrella Sampling Simulations

Cardiac troponin C (cTnC) binds intracellular calcium and subsequently cardiac troponin I (cTnI), initiating cardiac muscle contraction. Due to its role in contraction, cTnC has been a therapeutic target in the search for small molecules to treat conditions that interfere with normal muscle contract...

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Detalhes bibliográficos
Publicado no:J Chem Inf Model
Main Authors: Bowman, Jacob D., Coldren, William H., Lindert, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597294/
https://ncbi.nlm.nih.gov/pubmed/31141358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.9b00256
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