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Keratin 23 is a PPARA-dependent, MYC-amplified oncogene that promotes hepatocyte proliferation
Chronic activation of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARA) promotes MYC-linked hepatocellular carcinoma in mice. Recent studies have shown that MYC can function as an amplifier of transcription where MYC does not act as an ‘on-off’ switch for gene expression,...
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| Publicado no: | Hepatology |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6597269/ https://ncbi.nlm.nih.gov/pubmed/30697791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30530 |
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