Keratin 23 is a PPARA-dependent, MYC-amplified oncogene that promotes hepatocyte proliferation

Chronic activation of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARA) promotes MYC-linked hepatocellular carcinoma in mice. Recent studies have shown that MYC can function as an amplifier of transcription where MYC does not act as an ‘on-off’ switch for gene expression,...

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Pubblicato in:Hepatology
Autori principali: Kim, Donghwan, Brocker, Chad N., Takahashi, Shogo, Yagai, Tomoki, Kim, Taehyeong, Xie, Guomin, Wang, Hua, Qu, Aijuan, Gonzalez, Frank J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597269/
https://ncbi.nlm.nih.gov/pubmed/30697791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30530
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