Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model

Tau pathology was recently identified as a key driver of disease progression and an attractive therapeutic target in Alzheimer's disease (AD). Selenomethionine (Se-Met), a major bioactive form of selenium (Se) in organisms with significant antioxidant capacity, reduced the levels of total tau a...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhang, Zhong-Hao, Wu, Qiu-Yan, Zheng, Rui, Chen, Chen, Chen, Yao, Liu, Qiong, Hoffmann, Peter R., Ni, Jia-Zuan, Song, Guo-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596838/
https://ncbi.nlm.nih.gov/pubmed/28137967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3229-16.2017
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