Synaptic Regulator α-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells

Synaptic protein α-synuclein (α-SYN) modulates neurotransmission in a complex and poorly understood manner and aggregates in the cytoplasm of degenerating neurons in Parkinson′s disease. Here, we report that α-SYN present in dopaminergic nigral afferents is essential for the normal cycling and maint...

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Udgivet i:J Neurosci
Main Authors: Perez-Villalba, Ana, Sirerol-Piquer, M. Salomé, Belenguer, Germán, Soriano-Cantón, Raúl, Muñoz-Manchado, Ana Belén, Villadiego, Javier, Alarcón-Arís, Diana, Soria, Federico N., Dehay, Benjamin, Bezard, Erwan, Vila, Miquel, Bortolozzi, Analía, Toledo-Aral, Juan José, Pérez-Sánchez, Francisco, Fariñas, Isabel
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596232/
https://ncbi.nlm.nih.gov/pubmed/29217686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2276-17.2017
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