Probing the function of metazoan histones with a systematic library of H3 and H4 mutants

Replication-dependent histone genes often reside in tandemly arrayed gene clusters, hindering systematic loss-of-function analyses. Here, we used CRISPR/Cas9 and the attP/attB double-integration system to alter numbers and sequences of histone genes in their original genomic context in Drosophila me...

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Udgivet i:Dev Cell
Main Authors: Zhang, Weimin, Zhang, Xuedi, Xue, Zhaoyu, Li, Yijie, Ma, Qing, Ren, Xiangle, Zhang, Jiaying, Yang, Songhua, Yang, Lijuan, Wu, Menghua, Ren, Mengda, Xi, Rongwen, Wu, Zheng, Liu, Ji-Long, Matunis, Erika, Dai, Junbiao, Gao, Guanjun
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595499/
https://ncbi.nlm.nih.gov/pubmed/30595536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.11.047
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