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Mutagenicity and DNA Adduct Formation by Aristolochic Acid in the Spleen of Big Blue(®) Rats
Aristolochic acid (AA) is a potent human nephron-toxin and carcinogen. We previously reported that AA treatment resulted in DNA damage and mutation in the kidney and liver of rats. In this study, we have determined the DNA adducts and mutations induced by AA in rat spleen. Big Blue® transgenic rats...
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| Publicado no: | Environ Mol Mutagen |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595488/ https://ncbi.nlm.nih.gov/pubmed/22508110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21696 |
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