Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival After Islet Transplantation of Human and Mouse Islets

A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes. We hypothesized that this was a compensatory response and that HIF-1α protects β-cells during transplantation. Transplan...

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Publicat a:Cell Transplant
Autors principals: Stokes, Rebecca A., Cheng, Kim, Deters, Natasha, Lau, Sue Mei, Hawthorne, Wayne J., O’Connell, Philip J., Stolp, Jessica, Grey, Shane, Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Gonzalez, Frank J., Gunton, Jenny E.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6595221/
https://ncbi.nlm.nih.gov/pubmed/22710383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096368912X647180
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