Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1α protein are tightly regulated, recent studies suggest that it can be active under normoxic conditions. We hypothesized that HIF-1α is required for normal β cell functio...

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Detalhes bibliográficos
Main Authors: Cheng, Kim, Ho, Kenneth, Stokes, Rebecca, Scott, Christopher, Lau, Sue Mei, Hawthorne, Wayne J., O’Connell, Philip J., Loudovaris, Thomas, Kay, Thomas W., Kulkarni, Rohit N., Okada, Terumasa, Wang, Xiaohui L., Yim, Sun Hee, Shah, Yatrik, Grey, Shane T., Biankin, Andrew V., Kench, James G., Laybutt, D. Ross, Gonzalez, Frank J., Kahn, C. Ronald, Gunton, Jenny E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877560/
https://ncbi.nlm.nih.gov/pubmed/20440072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35846
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