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Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase (BSH) activity leading to the accumulation of intestinal tauro-β-muricholic acid (T-β-MCA). T-β-MCA is an farnesoid X rece...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595219/ https://ncbi.nlm.nih.gov/pubmed/24064762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3384 |
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