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Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-a...
Tallennettuna:
| Julkaisussa: | Nat Commun |
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| Päätekijät: | , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4682112/ https://ncbi.nlm.nih.gov/pubmed/26670557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10166 |
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