Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues

B-cell activation yields abundant cell death in parallel to clonal amplification and remodeling of immunoglobulin (Ig) genes by activation-induced deaminase (AID). AID promotes affinity maturation of Ig variable regions and class switch recombination (CSR) in mature B lymphocytes. In the IgH locus,...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Dalloul, Iman, Boyer, François, Dalloul, Zeinab, Pignarre, Amandine, Caron, Gersende, Fest, Thierry, Chatonnet, Fabrice, Delaloy, Céline, Durandy, Anne, Jeannet, Robin, Lereclus, Emilie, Boutouil, Hend, Aldigier, Jean-Claude, Péron, Sophie, Le Noir, Sandrine, Cook-Moreau, Jeanne, Cogné, Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594652/
https://ncbi.nlm.nih.gov/pubmed/31199803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007721
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