N‐methyl‐D‐aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit

Anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody‐mediated synaptic dysfunction. Cerebrospinal fluid–derived human monoclonal NR1 autoantibodies showed low numbers of somatic hypermutations or were unmutated. These unexpected g...

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Библиографические подробности
Опубликовано в: :Ann Neurol
Главные авторы: Wenke, Nina Kerstin, Kreye, Jakob, Andrzejak, Ewa, van Casteren, Adriana, Leubner, Jonas, Murgueitio, Manuela S., Reincke, S. Momsen, Secker, Christopher, Schmidl, Lars, Geis, Christian, Ackermann, Frauke, Nikolaus, Marc, Garner, Craig C., Wardemann, Hedda, Wolber, Gerhard, Prüss, Harald
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Inc. 2019
Предметы:
Brief Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593665/
https://ncbi.nlm.nih.gov/pubmed/30843274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25460
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