Affinities of human NMDA receptor autoantibodies: implications for disease mechanisms and clinical diagnostics

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a common autoimmune encephalitis presenting with psychosis, dyskinesias, autonomic dysfunction and seizures. The underlying autoantibodies against the NR1 subunit are directly pathogenic by disrupting synaptic NMDAR currents. However, antibo...

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Publicado en:J Neurol
Autores principales: Ly, Lam-Thanh, Kreye, Jakob, Jurek, Betty, Leubner, Jonas, Scheibe, Franziska, Lemcke, Johannes, Wenke, Nina Kerstin, Reincke, Sebastian Momsen, Prüss, Harald
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182686/
https://ncbi.nlm.nih.gov/pubmed/30187160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00415-018-9042-1
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