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A bypass mechanism of abiraterone‐resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling
BACKGROUND: Intratumoral steroidogenesis and its potential relevance in castration‐resistant prostate cancer (CRPC) and in cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)‐inhibitor treated hormone‐naïve and patients with CRPC are not well established. In this study, we tested if sub...
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| Publié dans: | Prostate |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6593470/ https://ncbi.nlm.nih.gov/pubmed/31017696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23799 |
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