A bypass mechanism of abiraterone‐resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling

BACKGROUND: Intratumoral steroidogenesis and its potential relevance in castration‐resistant prostate cancer (CRPC) and in cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1)‐inhibitor treated hormone‐naïve and patients with CRPC are not well established. In this study, we tested if sub...

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Publicat a:Prostate
Autors principals: Moll, Jan M., Kumagai, Jinpei, van Royen, Martin E., Teubel, Wilma J., van Soest, Robert J., French, Pim J., Homma, Yukio, Jenster, Guido, de Wit, Ronald, van Weerden, Wytske M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593470/
https://ncbi.nlm.nih.gov/pubmed/31017696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23799
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