Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

Replication origins, fragile sites, and rDNA have been implicated as sources of chromosomal instability. However, the defining genomic features of replication origins and fragile sites are among the least understood elements of eukaryote genomes. Here, we map sites of replication initiation and brea...

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Publicat a:Cell
Autors principals: Tubbs, Anthony, Sridharan, Sriram, van Wietmarschen, Niek, Maman, Yaakov, Callen, Elsa, Stanlie, Andre, Wu, Wei, Wu, Xia, Day, Amanda, Wong, Nancy, Yin, Mianmian, Canela, Andres, Fu, Haiqing, Redon, Christophe, Pruitt, Steven C., Jaszczyszyn, Yan, Aladjem, Mirit I., Aplan, Peter D., Hyrien, Olivier, Nussenzweig, André
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591735/
https://ncbi.nlm.nih.gov/pubmed/30078706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.07.011
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