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Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind
Two recent studies implicate PARP as sensors of incompletely processed Okazaki fragments, changing our view about how single-strand breaks arise in unperturbed cells. Unligated Okazaki fragments may trigger homologous recombination-mediated repair and underpin genome instability in BRCA1/BRCA2-defic...
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| Publicado no: | Mol Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589159/ https://ncbi.nlm.nih.gov/pubmed/30241603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.045 |
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