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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways...
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| Publicado no: | Nat Rev Mol Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591728/ https://ncbi.nlm.nih.gov/pubmed/28676700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2017.53 |
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