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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways...
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| Veröffentlicht in: | Nat Rev Mol Cell Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6591728/ https://ncbi.nlm.nih.gov/pubmed/28676700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2017.53 |
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