Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy

Previous studies on drug efficacy showed low protection against abortion and vertical transmission of Toxoplasma gondii in pregnant sheep. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Sánchez-Sánchez, Roberto, Ferre, Ignacio, Re, Michela, Ramos, Juan José, Regidor-Cerrillo, Javier, Pizarro Díaz, Manuel, González-Huecas, Marta, Tabanera, Enrique, Benavides, Julio, Hemphill, Andrew, Hulverson, Matthew A., Barrett, Lynn K., Choi, Ryan, Whitman, Grant R., Ojo, Kayode K., Van Voorhis, Wesley C., Ortega-Mora, Luis Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591617/
https://ncbi.nlm.nih.gov/pubmed/31061151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02527-18
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