Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy

Previous studies on drug efficacy showed low protection against abortion and vertical transmission of Toxoplasma gondii in pregnant sheep. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Sánchez-Sánchez, Roberto, Ferre, Ignacio, Re, Michela, Ramos, Juan José, Regidor-Cerrillo, Javier, Pizarro Díaz, Manuel, González-Huecas, Marta, Tabanera, Enrique, Benavides, Julio, Hemphill, Andrew, Hulverson, Matthew A., Barrett, Lynn K., Choi, Ryan, Whitman, Grant R., Ojo, Kayode K., Van Voorhis, Wesley C., Ortega-Mora, Luis Miguel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2019
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591617/
https://ncbi.nlm.nih.gov/pubmed/31061151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02527-18
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