Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis

Objectives: Establishment of a mouse model for congenital toxoplasmosis based on oral infection with oocysts from Toxoplasma gondii ME49 and its application for investigating chemotherapeutic options against congenital toxoplasmosis. Methods: CD1 mice were mated, orally infected with 5, 25, 100, 500...

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Foilsithe in:J Antimicrob Chemother
Main Authors: Müller, Joachim, Aguado-Martínez, Adriana, Ortega-Mora, Luis-Miguel, Moreno-Gonzalo, Javier, Ferre, Ignacio, Hulverson, Matthew A., Choi, Ryan, McCloskey, Molly C., Barrett, Lynn K., Maly, Dustin J., Ojo, Kayode K., Van Voorhis, Wes, Hemphill, Andrew
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2017
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890665/
https://ncbi.nlm.nih.gov/pubmed/28486633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx134
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