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Shortening Buruli Ulcer Treatment with Combination Therapy Targeting the Respiratory Chain and Exploiting Mycobacterium ulcerans Gene Decay

Buruli ulcer is treatable with antibiotics. An 8-week course of rifampin (RIF) and either streptomycin (STR) or clarithromycin (CLR) cures over 90% of patients. However, STR requires injections and may be toxic, and CLR shares an adverse drug-drug interaction with RIF and may be poorly tolerated. St...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Converse, Paul J., Almeida, Deepak V., Tyagi, Sandeep, Xu, Jian, Nuermberger, Eric L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591589/
https://ncbi.nlm.nih.gov/pubmed/31036687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00426-19
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