The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecular platform to scaffold all the components of the PI3K-A...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chen, Mo, Choi, Suyong, Jung, Oisun, Wen, Tianmu, Baum, Christina, Thapa, Narendra, Lambert, Paul F., Rapraeger, Alan C., Anderson, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591252/
https://ncbi.nlm.nih.gov/pubmed/31235839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45671-5
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