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Ca(2+)-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1

IQ domain GTPase-activating scaffolding protein 1 (IQGAP1) mediates cytoskeleton, cell migration, proliferation, and apoptosis events. Calmodulin (CaM) modulates IQGAP1 functions by binding to its four tandem IQ motifs. Exactly how CaM binds the IQ motifs and which functions of IQGAP1 CaM regulates...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Zhang, Mingzhen, Li, Zhigang, Jang, Hyunbum, Hedman, Andrew C., Sacks, David B., Nussinov, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195445/
https://ncbi.nlm.nih.gov/pubmed/31724397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00854
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