Ca(2+)-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1

IQ domain GTPase-activating scaffolding protein 1 (IQGAP1) mediates cytoskeleton, cell migration, proliferation, and apoptosis events. Calmodulin (CaM) modulates IQGAP1 functions by binding to its four tandem IQ motifs. Exactly how CaM binds the IQ motifs and which functions of IQGAP1 CaM regulates...

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Bibliografiset tiedot
Julkaisussa:Biochemistry
Päätekijät: Zhang, Mingzhen, Li, Zhigang, Jang, Hyunbum, Hedman, Andrew C., Sacks, David B., Nussinov, Ruth
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195445/
https://ncbi.nlm.nih.gov/pubmed/31724397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00854
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