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Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions

Diverse antibody repertoires are generated through remote genomic interactions involving immunoglobulin variable (V(H)), diversity (D(H)) and joining (J(H)) gene segments. How such interactions are orchestrated remains unknown. Here we develop a strategy to track V(H)-D(H)J(H) motion in B-lymphocyte...

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Publicado en:Nat Commun
Main Authors: Khanna, Nimish, Zhang, Yaojun, Lucas, Joseph S., Dudko, Olga K., Murre, Cornelis
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591236/
https://ncbi.nlm.nih.gov/pubmed/31235807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10628-9
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