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Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP

P2X3 receptor channels expressed in sensory neurons are activated by extracellular ATP and serve important roles in nociception and sensory hypersensitization, making them attractive therapeutic targets. Although several P2X3 structures are known, it is unclear how physiologically abundant Ca(2+)-AT...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Li, Mufeng, Wang, Yao, Banerjee, Rahul, Marinelli, Fabrizio, Silberberg, Shai, Faraldo-Gómez, José D, Hattori, Motoyuki, Swartz, Kenton Jon
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590987/
https://ncbi.nlm.nih.gov/pubmed/31232692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47060
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