Mast cell degranulation and fibroblast activation in the morphine-induced spinal mass: Role of Mas-related G protein-coupled receptor signaling.

BACKGROUND: As the meningeally-derived, fibroblast-rich, mass-produced by intrathecal morphine infusion is not produced by all opiates, but reduced by mast cell stabilizers, we hypothesized a role for meningeal mast cell/fibroblast activation. Using the guinea pig, we asked: i) Are IT morphine masse...

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Veröffentlicht in:Anesthesiology
Hauptverfasser: Yaksh, Tony L., Eddinger, Kelly A., Kokubu, Shinichi, Wang, Zhenping, DiNardo, Anna, Ramachandran, Roshni, Zhu, Yuelian, He, Yajun, Weren, Fieke, Quang, Daphne, Malkmus, Shelle A., Lansu, Katherine, Kroeze, Wesley K., Eliceiri, Brian, Steinauer, Joanne J., Schiller, Peter W., Gmeiner, Peter, Page, Linda M., Hildebrand, Keith R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590697/
https://ncbi.nlm.nih.gov/pubmed/31225809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002730
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