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A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop
Monopolar spindle 1 (Mps1) is a dual‐specificity protein kinase, orchestrating faithful chromosome segregation during mitosis. All reported structures of the Mps1 kinase adopt the hallmarks of an inactive conformation, which includes a mostly disordered activation loop. Here, we present a 2.4 Å reso...
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| Publicado no: | Proteins |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6590424/ https://ncbi.nlm.nih.gov/pubmed/30582207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25651 |
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