Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

Monopolar spindle 1 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signaling, preventing anaphase until all chromosomes are properly attached to spindle microtubules. Mps1 has emerged as a potential target for cancer therapy, and a variety of compounds have been developed to inhibit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Hiruma, Yoshitaka, Koch, Andre, Hazraty, Nazila, Tsakou, Foteini, Medema, René H., Joosten, Robbie P., Perrakis, Anastassis
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Molecular Biophysics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582842/
https://ncbi.nlm.nih.gov/pubmed/28726638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783555
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