Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

Immortalizing primary cells with human telomerase reverse transcriptase (hTERT) has been common practice to enable primary cells to be of extended use in the laboratory because they avoid replicative senescence. Studying exogenously expressed hTERT in cells also affords scientists models of early ca...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Genes Chromosomes Cancer
Päätekijät: Bikkul, Mehmet U., Faragher, Richard G. A., Worthington, Gemma, Meinke, Peter, Kerr, Alastair R. W., Sammy, Aakila, Riyahi, Kumars, Horton, Daniel, Schirmer, Eric C., Hubank, Michael, Kill, Ian R., Anderson, Rhona M., Slijepcevic, Predrag, Makarov, Evgeny, Bridger, Joanna M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley & Sons, Inc. 2019
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590296/
https://ncbi.nlm.nih.gov/pubmed/30474255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22711
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia