Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

Immortalizing primary cells with human telomerase reverse transcriptase (hTERT) has been common practice to enable primary cells to be of extended use in the laboratory because they avoid replicative senescence. Studying exogenously expressed hTERT in cells also affords scientists models of early ca...

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Vydáno v:Genes Chromosomes Cancer
Hlavní autoři: Bikkul, Mehmet U., Faragher, Richard G. A., Worthington, Gemma, Meinke, Peter, Kerr, Alastair R. W., Sammy, Aakila, Riyahi, Kumars, Horton, Daniel, Schirmer, Eric C., Hubank, Michael, Kill, Ian R., Anderson, Rhona M., Slijepcevic, Predrag, Makarov, Evgeny, Bridger, Joanna M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590296/
https://ncbi.nlm.nih.gov/pubmed/30474255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22711
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