Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement system. In more than half of C3G patients C3...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Michels, Marloes A. H. M., van de Kar, Nicole C. A. J., van den Bos, Ramon M., van der Velden, Thea J. A. M., van Kraaij, Sanne A. W., Sarlea, Sebastian A., Gracchi, Valentina, Oosterveld, Michiel J. S., Volokhina, Elena B., van den Heuvel, Lambertus P. W. J.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590259/
https://ncbi.nlm.nih.gov/pubmed/31263464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01350
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