Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases

Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors (C3NeF) play an important role in C3G pathogenesis by stabilizing the key enzymatic complex of compleme...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Michels, Marloes A. H. M., van de Kar, Nicole C. A. J., Okrój, Marcin, Blom, Anna M., van Kraaij, Sanne A. W., Volokhina, Elena B., van den Heuvel, Lambertus P. W. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893837/
https://ncbi.nlm.nih.gov/pubmed/29670616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00612
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