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Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement system. In more than half of C3G patients C3...

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Publicado no:Front Immunol
Main Authors: Michels, Marloes A. H. M., van de Kar, Nicole C. A. J., van den Bos, Ramon M., van der Velden, Thea J. A. M., van Kraaij, Sanne A. W., Sarlea, Sebastian A., Gracchi, Valentina, Oosterveld, Michiel J. S., Volokhina, Elena B., van den Heuvel, Lambertus P. W. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590259/
https://ncbi.nlm.nih.gov/pubmed/31263464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01350
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