Phospholipase C (PLC)ɛ Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line

BACKGROUND: Primary therapy for patients with advanced prostate cancer (PCa) consists of androgen deprivation therapy targeting the androgen receptor (AR) axis. However, most tumors progress to castration-resistant prostate cancer (CRPC) within 18–24 months. The purpose of the present study was to i...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Yuan, Mengjuan, Gao, Yingying, Li, Luo, Sun, Wei, Cheng, Honglin, Li, Ting, Niu, Lingfang, Du, Zhongbo, Quan, Zhen, Luo, Chunli, Wu, Xiaohou
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2019
Assuntos:
Lab/In Vitro Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590100/
https://ncbi.nlm.nih.gov/pubmed/31201297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.915828
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