Hypomethylating agent alters the immune microenvironment in AML and enhances the immunogenicity of a DC/AML vaccine

Acute myeloid leukemia (AML) is a lethal hematologic malignancy characterized by an immunosuppressive milieu in the tumor microenvironment (TME) that fosters disease growth and therapeutic resistance. Hypomethylating agents (HMAs) demonstrate clinical efficacy in AML patients and exert immunomodulat...

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Udgivet i:Br J Haematol
Main Authors: Nahas, Myrna R., Stroopinsky, Dina, Rosenblatt, Jacalyn, Cole, Leandra, Pyzer, Athalia R., Anastasiadou, Eleni, Sergeeva, Anna, Ephraim, Adam, Washington, Abigail, Orr, Shira, McMasters, Malgorzata, Weinstock, Matthew, Jain, Salvia, Leaf, Rebecca Karp, Ghiasuddin, Haider, Rahimian, Maryam, Liegel, Jessica, Molldrem, Jeffrey J., Slack, Frank, Avigan, David
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590084/
https://ncbi.nlm.nih.gov/pubmed/30828801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15818
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