Hypomethylating agent alters the immune microenvironment in AML and enhances the immunogenicity of a DC/AML vaccine

Acute myeloid leukemia (AML) is a lethal hematologic malignancy characterized by an immunosuppressive milieu in the tumor microenvironment (TME) that fosters disease growth and therapeutic resistance. Hypomethylating agents (HMAs) demonstrate clinical efficacy in AML patients and exert immunomodulat...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Nahas, Myrna R., Stroopinsky, Dina, Rosenblatt, Jacalyn, Cole, Leandra, Pyzer, Athalia R., Anastasiadou, Eleni, Sergeeva, Anna, Ephraim, Adam, Washington, Abigail, Orr, Shira, McMasters, Malgorzata, Weinstock, Matthew, Jain, Salvia, Leaf, Rebecca Karp, Ghiasuddin, Haider, Rahimian, Maryam, Liegel, Jessica, Molldrem, Jeffrey J., Slack, Frank, Avigan, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590084/
https://ncbi.nlm.nih.gov/pubmed/30828801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15818
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