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Hypomethylating agent alters the immune microenvironment in AML and enhances the immunogenicity of a DC/AML vaccine

Acute myeloid leukemia (AML) is a lethal hematologic malignancy characterized by an immunosuppressive milieu in the tumor microenvironment (TME) that fosters disease growth and therapeutic resistance. Hypomethylating agents (HMAs) demonstrate clinical efficacy in AML patients and exert immunomodulat...

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Bibliografische gegevens
Gepubliceerd in:Br J Haematol
Hoofdauteurs: Nahas, Myrna R., Stroopinsky, Dina, Rosenblatt, Jacalyn, Cole, Leandra, Pyzer, Athalia R., Anastasiadou, Eleni, Sergeeva, Anna, Ephraim, Adam, Washington, Abigail, Orr, Shira, McMasters, Malgorzata, Weinstock, Matthew, Jain, Salvia, Leaf, Rebecca Karp, Ghiasuddin, Haider, Rahimian, Maryam, Liegel, Jessica, Molldrem, Jeffrey J., Slack, Frank, Avigan, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590084/
https://ncbi.nlm.nih.gov/pubmed/30828801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15818
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