Hypomethylating agent alters the immune microenvironment in AML and enhances the immunogenicity of a DC/AML vaccine

Acute myeloid leukemia (AML) is a lethal hematologic malignancy characterized by an immunosuppressive milieu in the tumor microenvironment (TME) that fosters disease growth and therapeutic resistance. Hypomethylating agents (HMAs) demonstrate clinical efficacy in AML patients and exert immunomodulat...

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Veröffentlicht in:Br J Haematol
Hauptverfasser: Nahas, Myrna R., Stroopinsky, Dina, Rosenblatt, Jacalyn, Cole, Leandra, Pyzer, Athalia R., Anastasiadou, Eleni, Sergeeva, Anna, Ephraim, Adam, Washington, Abigail, Orr, Shira, McMasters, Malgorzata, Weinstock, Matthew, Jain, Salvia, Leaf, Rebecca Karp, Ghiasuddin, Haider, Rahimian, Maryam, Liegel, Jessica, Molldrem, Jeffrey J., Slack, Frank, Avigan, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590084/
https://ncbi.nlm.nih.gov/pubmed/30828801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15818
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