Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation

Junctional adhesion molecule-A (JAM-A), an epithelial tight junction protein, plays an important role in regulating intestinal permeability through association with a scaffold signaling complex containing ZO-2, Afadin, and the small GTPase Rap2. Under inflammatory conditions, we report that the cyto...

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Udgivet i:Mol Biol Cell
Main Authors: Fan, Shuling, Weight, Caroline M., Luissint, Anny-Claude, Hilgarth, Roland S., Brazil, Jennifer C., Ettel, Mark, Nusrat, Asma, Parkos, Charles A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589701/
https://ncbi.nlm.nih.gov/pubmed/30625033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-08-0531
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