Preformed chromatin topology assists transcriptional robustness of Shh during limb development

Long-range gene regulation involves physical proximity between enhancers and promoters to generate precise patterns of gene expression in space and time. However, in some cases, proximity coincides with gene activation, whereas, in others, preformed topologies already exist before activation. In thi...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Paliou, Christina, Guckelberger, Philine, Schöpflin, Robert, Heinrich, Verena, Esposito, Andrea, Chiariello, Andrea M., Bianco, Simona, Annunziatella, Carlo, Helmuth, Johannes, Haas, Stefan, Jerković, Ivana, Brieske, Norbert, Wittler, Lars, Timmermann, Bernd, Nicodemi, Mario, Vingron, Martin, Mundlos, Stefan, Andrey, Guillaume
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589666/
https://ncbi.nlm.nih.gov/pubmed/31147463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900672116
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