An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression

Short digits (Dsh) is a radiation-induced mouse mutant. Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation. Heterozygous mice show a limb reduction phenotype with fusion and shortening of the proximal and middle phalanges...

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Bibliografiska uppgifter
Huvudupphovsmän: Niedermaier, Michael, Schwabe, Georg C., Fees, Stephan, Helmrich, Anne, Brieske, Norbert, Seemann, Petra, Hecht, Jochen, Seitz, Volkhard, Stricker, Sigmar, Leschik, Gundula, Schrock, Evelin, Selby, Paul B., Mundlos, Stefan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2005
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1070420/
https://ncbi.nlm.nih.gov/pubmed/15841179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523675
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