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An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression
Short digits (Dsh) is a radiation-induced mouse mutant. Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation. Heterozygous mice show a limb reduction phenotype with fusion and shortening of the proximal and middle phalanges...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1070420/ https://ncbi.nlm.nih.gov/pubmed/15841179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523675 |
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