Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics

Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the unifo...

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Published in:Mol Biol Cell
Main Authors: Ly, Thu, Pappas, Christopher T., Johnson, Dylan, Schlecht, William, Colpan, Mert, Galkin, Vitold E., Gregorio, Carol C., Dong, Wen-Ji, Kostyukova, Alla S.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589558/
https://ncbi.nlm.nih.gov/pubmed/30462572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-06-0406
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