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Structural destabilization of tropomyosin induced by the cardiomyopathy‐linked mutation R21H
The missense mutation R21H in striated muscle tropomyosin is associated with hypertrophic cardiomyopathy, a genetic cardiac disease and a leading cause of sudden cardiac death in young people. Tropomyosin adopts conformation of a coiled coil which is critical for regulation of muscle contraction. In...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5775174/ https://ncbi.nlm.nih.gov/pubmed/29105867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3341 |
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