Structural destabilization of tropomyosin induced by the cardiomyopathy‐linked mutation R21H

The missense mutation R21H in striated muscle tropomyosin is associated with hypertrophic cardiomyopathy, a genetic cardiac disease and a leading cause of sudden cardiac death in young people. Tropomyosin adopts conformation of a coiled coil which is critical for regulation of muscle contraction. In...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Ly, Thu, Krieger, Inna, Tolkatchev, Dmitri, Krone, Cheyenna, Moural, Timothy, Samatey, Fadel A., Kang, ChulHee, Kostyukova, Alla S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775174/
https://ncbi.nlm.nih.gov/pubmed/29105867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3341
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