Hepatotoxicity and Toxicology of In Vivo Lentiviral Vector Administration in Healthy and Liver-Injury Mouse Models

General safety and toxicology assessments supporting in vivo lentiviral vector-based therapeutic development are sparse. We have previously demonstrated the efficacy of a lentiviral vector expressing fumarylacetoacetate hydrolase (LV-FAH) to cure animal models of hereditary tyrosinemia type 1. There...

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Detaylı Bibliyografya
Yayımlandı:Hum Gene Ther Clin Dev
Asıl Yazarlar: Kaiser, Robert Allen, Nicolas, Clara Teresa, Allen, Kari Lynn, Chilton, Jennifer Anne, Du, Zeji, Hickey, Raymond Daniel, Lillegard, Joseph Benjamin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc., publishers 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589498/
https://ncbi.nlm.nih.gov/pubmed/30860398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2018.249
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