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Chimeric antigen receptors designed to overcome transforming growth factor‐β‐mediated repression in the adoptive T‐cell therapy of solid tumors

Adoptive cell therapy with chimeric antigen receptor (CAR)‐engineered T cells produced lasting remissions in the treatment of advanced, so far refractory B‐cell malignancies; however, the elimination of solid tumors remains so far elusive. The low efficacy of CAR T cells is thought to be due to the...

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Bibliografiske detaljer
Udgivet i:Clin Transl Immunology
Main Authors: Hartley, Jordan, Abken, Hinrich
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589154/
https://ncbi.nlm.nih.gov/pubmed/31236274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1064
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