Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm embryo in response to the transcriptional activator...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Park, Jeehae, Estrada, Javier, Johnson, Gemma, Vincent, Ben J, Ricci-Tam, Chiara, Bragdon, Meghan DJ, Shulgina, Yekaterina, Cha, Anna, Wunderlich, Zeba, Gunawardena, Jeremy, DePace, Angela H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2019
Onderwerpen:
Chromosomes and Gene Expression
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588347/
https://ncbi.nlm.nih.gov/pubmed/31223115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41266
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