Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm embryo in response to the transcriptional activator...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Park, Jeehae, Estrada, Javier, Johnson, Gemma, Vincent, Ben J, Ricci-Tam, Chiara, Bragdon, Meghan DJ, Shulgina, Yekaterina, Cha, Anna, Wunderlich, Zeba, Gunawardena, Jeremy, DePace, Angela H
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2019
Ämnen:
Chromosomes and Gene Expression
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588347/
https://ncbi.nlm.nih.gov/pubmed/31223115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41266
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